AGREEMENT FOR OPEN ACCESS TO THE INDIAN GENOME VARIATION DATABASE ['IGVDB'] OF THE COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, INDIA ['CSIR']|
¢ This site is owned by the Institute of Genomics and Integrative Biology ['IGIB'], a constituent laboratory of the Council of Scientific and Industrial Research, India, an autonomous body registered under the Registration of Societies Act [XXI of 1860], having its registered office at Anusandhan Bhawan, 2, Rafi Marg, New Delhi - 110001. All materials appearing on this site, including site design, text, graphics, icons interfaces, and the selection, assembly and arrangements are owned by IGIB, CSIR.
¢ The Indian Genome Variation database (IGVDB) is a consortium activity established in 2003 deemed it pertinent to understand the inherent genetic variability of the Indian subpopulations; as a first step towards identifying susceptible biomarkers for any disease or understanding drug response in different subpopulations. This is the first large scale comprehensive study of the structure of the Indian population.
¢ The Indian Genome Variation initiative is a network program, tenured for 5 years, by six constituent laboratories of the Council of Scientific and Industrial Research (CSIR). The laboratories include Institute of Genomics and Integrative Biology (IGIB), Delhi, Centre for Cellular and Molecular Biology (CCMB), Hyderabad, Indian Institute of Chemical Biology (IICB), Kolkata, Central Drug Research Institute (CDRI), Lucknow, Industrial Toxicological Research Centre (ITRC), Lucknow and Institute of Microbial technology (IMTECH), Chandigarh.
¢ This consortium, aims at providing information on variations in the Indian subpopulations representing the entire country. These variations would be useful for investigators for specific candidate gene studies conducted in any part of the country.
¢ In addition to providing information on informative SNPs in more than 1000 genes, it also contains validated SNPs spanning the entire genome and regions of copy number polymorphisms.
¢ The populations taken into account are both large (population size more than a million) and small (_______________) and isolated on the basis of four major linguistic groups:
¢ Majority of the genes have been selected on the basis of their relevance as functional and positional candidates in many common diseases including genes relevant to pharmacogenomics. The ultimate goal is to create a DNA variation database of the Indian population and make it available to researchers for understanding human biology with respect to disease predisposition, adverse drug reaction, population migration etc.
¢ The IGVDB database constitutes:
o Individual Population Details
o Individual Gene Details
o SNP Details
o Population wise allele frequency
o Population wise genotype frequency
o Population wise genotype data.
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